ABSTRACT
ABSTRACT This work aimed to compare performances on the Timed Up and Go (TUG) test and its subtasks between faller and non-faller older adults with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). A prospective study was conducted, with 38 older adults with MCI and 37 with mild AD. Participants underwent an assessment at baseline (the TUG and its subtasks using the Qualisys ProReflex system) and the monitoring of falls at the six-month follow up. After six months, 52.6% participants with MCI and 51.3% with AD fell. In accordance with specific subtasks, total performance on the TUG distinguished fallers from non-fallers with AD, fallers from non-fallers with MCI and non-fallers with MCI from non-fallers with AD. Although no other difference was found in total performances, non-fallers with MCI and fallers with AD differed on the walking forward, turn and turn-to-sit subtasks; and fallers with MCI and non-fallers with AD differed on the turn-to-sit subtask.
RESUMO O objetivo deste trabalho foi comparar o desempenho do Timed up and go test (TUG) e suas subtarefas entre idosos caidores e não caidores com comprometimento cognitivo leve (CCL) e doença de Alzheimer (DA) leve. Um estudo prospectivo foi conduzido, com 38 idosos com CCL e 37 com DA leve. Foi realizada uma avaliação inicial (TUG e subtarefas por meio do sistema Qualisys Pro Reflex) e um monitoramento de quedas por 6 meses. Após 6 meses, 52.6% pessoas com CCL e 51.3% com DA caíram. Em concordância com subtarefas específicas, a performance total do TUG distinguiu caidores de não caidores com DA, caidores de não caidores com CCL e não caidores com CCL de não caidores com DA. Embora nenhuma outra diferença foi encontrada na performance total do TUG, não caidores com CCL e caidores com DA apresentaram diferenças nas performances das subtarefas marcha ida, retornar e virar-se para sentar; e caidores com CCL e não caidores com DA diferiram na subtarefa virar-se para sentar.
Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Accidental Falls/statistics & numerical data , Geriatric Assessment/methods , Postural Balance/physiology , Exercise Test/methods , Alzheimer Disease/diagnosis , Cognitive Dysfunction/diagnosis , Psychiatric Status Rating Scales , Prospective Studies , Alzheimer Disease/complications , Alzheimer Disease/physiopathology , Cognitive Dysfunction/complications , Cognitive Dysfunction/physiopathologyABSTRACT
ABSTRACT Language assessment seems to be an effective tool to differentiate healthy and cognitively impaired aging groups. This article discusses the impact of educational level on a naming task, on a verbal learning with semantic cues task and on the MMSE in healthy aging adults at three educational levels (very low, low and high) as well as comparing two clinical groups of very low (0-3 years) and low education (4-7 years) patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) with healthy controls. The participants comprised 101 healthy controls, 17 patients with MCI and 19 with AD. Comparisons between the healthy groups showed an education effect on the MMSE, but not on naming and verbal learning. However, the clinical groups were differentiated in both the naming and verbal learning assessment. The results support the assumption that the verbal learning with semantic cues task is a valid tool to diagnose MCI and AD patients, with no influence from education.
RESUMO A linguagem tem se mostrado uma ferramenta eficiente para diferenciar grupos de idosos saudáveis dos com deficiências cognitivas. O artigo objetiva discutir o impacto do nível educacional na nomeação, na aprendizagem verbal (AV) com pistas semânticas e no MEEM no envelhecimento saudável em três níveis de escolaridade (muito baixa: 0-3 anos, baixa: 4-7 anos e alta: >8 anos) e em dois grupos clínicos de escolaridade muito baixa e baixa (Doença de Alzheimer - DA - e Comprometimento Cognitivo Leve - CCL), comparados a controles saudáveis. Participaram 101 controles, 17 CCL e 19 DA. Comparações entre grupos saudáveis demonstraram um efeito da escolaridade no MEEM, mas não nas tarefas de nomeação e de AV. Considerando as comparações entre os grupos clínicos, tanto a nomeação quanto a AV os diferenciaram. Os resultados corroboram a pressuposição de que a tarefa de AV com pistas semânticas é válida para diagnosticar CCL e DA, não sendo influenciada pela escolaridade.
Subject(s)
Humans , Male , Female , Adult , Verbal Learning/physiology , Aging/physiology , Educational Status , Alzheimer Disease/physiopathology , Cognitive Dysfunction/physiopathology , Psychiatric Status Rating Scales , Reference Values , Semantics , Task Performance and Analysis , Brazil , Aging/psychology , Case-Control Studies , Analysis of Variance , Alzheimer Disease/psychology , Memory, Episodic , Cognitive Dysfunction/psychology , Healthy Aging/physiology , Healthy Aging/psychology , Language Tests , Neuropsychological TestsABSTRACT
Objective To investigate the effect of anesthesia at different depths on postoperative cognitive disfunction (POCD) and inflammatory response in the elderly patients undergoing abdominal operation.Methods A total of 90 elderly patients who underwent abdominal operation in the Affiliated Hospital of Shaanxi University of Chinese Medicine from June 2014 to June 2016 were divided into observation group and control group according to the depth of anesthesia,45 cases in each group.The patients in the two groups were performed with combined intravenous and inhalation anesthesia,the bispeetral index (BIS) value was maintained at 30-39 during the operation in the observation group,and the BIS value was maintained at 50-59 during the operation in the control group.The mean arterial pressure (MAP) and heart rate(HR) of patients in the two groups were recorded at the time points of entering the operation room(T0),5 minutes after tracheal cannula(T1),opening abdominal cavity (T2),closing abdominal cavity (T3) and tracheal cannula extubation (T4).The mini-mental state examination (MMSE) score of the patients in the two groups was performed before operation and the first,third,seventh day after operation;and the incidence of POCD was recorded.The levels of serum interleukin-6(IL-6) and S-100β protein were detected at the time points of before operation,the end of the operation and the first,third day after operation in the two groups.Results Five cases in the control group and six cases in the observation group were eliminated,39 cases in the observation group and 40 cases in the control group were evaluated finally.The MAP at T1 and T2 was significantly lower than that at T0 in the two groups (P ＜ 0.05).There was no significant difference in the MAP between T3,T4 and T0 in the two groups(P ＜ 0.05).There was no significant difference in the HR each time point in each group(P ＜ 0.05).There was no significant difference in the MAP and HR between the two groups at each time point(P ＜ 0.05).There was no significant difference in the MMSE score between the two groups before operation(P ＜ 0.05).The MMSE score of patients at the first and third day after operation was significantly lower than that before operation and the seventh day after operation in the two groups (P ＜ 0.05).There was no significant difference in the MMSE score between before operation and the seventh day after operation in the two groups(P ＜0.05).The MMSE score in the observation group was significantly higher than that in the control group at the first and third day after operation (P ＜ 0.05).There was no significant difference in the MMSE score between the two groups at the seventh day after opera tion(P ＜ 0.05).The incidences of POCD at the first,third and seventh day after operation in the observation group were 28.21％ (11/39),15.38％ (6/39) and 7.69％ (3/39) respectively;and they were 50.00％ (20/40),37.50％ (15/40) and 20.00％ (8/40) respectively in the control group.The incidence of POCD in the observation group was significantly lower than that in the control group at the first and third day after operation (x =3.934,4.949;P ＜ 0.05).There was no significant difference in the incidence of POCD between the two groups at the seventh day after operation(x2 =2.496,P ＜ 0.05).There was no significant difference in the levels of serum IL-6 and S-100β protein between the two groups before operation (P ＜0.05).The levels of serum IL-6 and S-100β protein at the end of operation and the first,third day after operation were significantly higher than those before operation in the two groups(P ＜ 0.05).The levels of serum IL-6 and S-100β protein in the observation group were significantly lower than those in the control group at the end of operation and the first,third day after operation (P ＜ 0.05).Conclusion Deep anesthesia (BIS value is maintained at 30-39) can reduce the levels of inflammatory factors,the incidence of POCD after operation and the brain damage in the elderly patients with abdominal operation.
ABSTRACT
La enfermedad de Parkinson es la segunda enfermedad degenerativa más común en el mundo después del Alzheimer. En Colombia hay una prevalencia estimada de 4,7 (IC95%: 2,2 a 8,9) por 1,000 habitantes y se detecta con mayor frecuencia en personas mayores de 60 años, lo que representa un alto costo para las familias y para el sistema de salud. Actualmente se utilizan para el diagnóstico los criterios del Banco de Cerebros del Reino Unido, sin embargo, hay otros criterios que pueden ser útiles para proyectos de investigación. Se ha demostrado que hay múltiples factores de riesgo y de progresión asociados con la enfermedad, y que deben tenerse en cuenta durante la evaluación clínica, la cual debería siempre realizarse en conjunto con las escalas de seguimiento.
Parkinson's disease is the second most common degenerative disease in the world after Alzheimer's disease. Colombia has an estimated prevalence of 470 (95% CI 2.2 to 8.9) per 1,000 people, more frequently found in people over 60 years, which represents a high financial burden imposed on families and health care system. The criteria currently used for the diagnostic are those compiled in the Brain Bank of the UK; however, other criteria may be useful for research. There are multiple risk and progression factors which have been proven to have an association with parkinson's disease, and that should be considered during clinical assessment, which should always be carried out additionally with follow scales.
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Objective To investigate the prevalence and relative factors of cognitive disfunction among the community-dwelling old adults. Methods 766 participants over 60 years old dwelling in Luzhou, Sichuan, China were enrolled with Multi-stage stratified sampling. Information about sociodemographic characteristics, lifestyle, health condition, nutrition were interviewed, and their cognitive function was evaluated with Mini-Mental State Examination (MMSE). Results The prevalence of cognitive disfunction was 19.7%among them. Gender (male vs. female, OR=0.577), age (over 90 years vs. 60-64 years, OR=29.857), administrator (administrator vs. not administrator, OR=0.360), farmer (farmer vs. not farmer, OR=2.121), nutrition (malnutrition vs. eutrophia, OR=2.460), body weight (underweight vs. normal weight, OR=3.222), living status (UN-Habitat vs. living alone, OR=0.658), marital status (widowed vs. not widowed, OR=2.208), education attainment (junior college vs. illiteracy, OR=0.328), income (over 1000 yuan vs. no income, OR=0.596) significantly related with cognitive disfunction (P<0.05). Multiple Logistic regression analysis showed that old age, occupation (farmer) and malnutrition were independent risk factors for cognitive disfunction. Conclusion The cognitive disfunction related with multi-factors, and need more effective and available in-tervention in the old adults.